Analgesic efficacy of ketoprofen in postpartum, general surgery, and chronic cancer pain

This article summarizes the results of five single-dose clinical studies of three pain models: postpartum, postoperative, and chronic cancer pain. The efficacy of ketoprofen (in varying doses from 25 to 225 mg) was compared with one of the following standards: aspirin (650 mg), codeine (90 mg), acetaminophen (650 mg) plus codeine (60 mg), and parenteral morphine (5 mg and 10 mg). The results indicate that ketoprofen in doses as low as 25 mg has analgesic properties significantly superior to those of placebo. For the treatment of postpartum pain, ketoprofen was significantly more effective than aspirin 650 mg but not significantly different from codeine 90 mg. Ketoprofen doses of 50 mg and 150 mg also provided analgesia superior to that with acetaminophen 650 mg plus codeine 60 mg for the management of moderate to severe postoperative pain. Moreover, oral doses of ketoprofen (75 and 225 mg) provided analgesia similar to that obtained with 5 and 10 mg parenteral doses of morphine. Adverse effects related to ketoprofen were relatively minor and infrequent. Ketoprofen was recently approved for use as an analgesic for treatment of mild to moderate pain in total daily doses up to 300 mg; the recommended initial dose is 25 to 50 mg every 6 to 8 hours as necessary.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				C. M. Spofford, H. Ashmawi, A. Subieta, F. Buevich, A. Moses, M. Baker, and T. J. Brennan Ketoprofen Produces Modality-Specific Inhibition of Pain Behaviors in Rats After Plantar Incision Anesth. Analg., December 1, 2009; 109(6): 1992 - 1999. [Abstract] [Full Text] [PDF]

				C. Urch The pathophysiology of cancer-induced bone pain: current understanding Palliative Medicine, June 1, 2004; 18(4): 267 - 274. [Abstract] [PDF]

				C. A Jenkins and E. Bruera Nonsteroidal anti-inflammatory drugs as adjuvant analgesics in cancer patients Palliative Medicine, April 1, 1999; 13(3): 183 - 196. [Abstract] [PDF]

				V. Pace Use of nonsteroidal anti-inflammatory drugs in cancer Palliative Medicine, October 1, 1995; 9(4): 273 - 286. [Abstract] [PDF]