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Treatment of depression in chronic cocaine and phencyclidine abuse with desipramine

AJ Giannini, DA Malone, MC Giannini, WA Price, and RH Loiselle

An open field trial was conducted comparing desipramine and an active placebo in separate populations of chronic cocaine and phencyclidine (PCP) abusers, who discontinued their abuse. Subjects who received desipramine showed a decrease in depressive symptoms after a 20-40 day period regardless of whether they abused PCP or cocaine.
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