J Clin Pharmacol
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Bumetanide in refractory ascites of cirrhosis of the liver: a comparison with furosemide

FL Iber and RA Baum

Bumetanide and furosemide were compared in the treatment of resistant ascites in patients with liver disease of alcoholic origin. In a prospective randomized trial, no significant difference was found in the ability of these two agents to promote natriuresis or diuresis. The duration of action was 12 hours for bumetanide and 6 hours for furosemide, but this difference was of no clinical significance.
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