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An evaluation of the analgesic efficacy of proquazone and aspirin in postoperative dental pain

JA Forbes, RW White, EH White, and MK Hughes

The analgesic efficacy of 75, 150, and 300 mg proquazone, a new nonsteroidal antiinflammatory agents, was compared to that of 650 mg aspirin and a placebo in outpatients who had moderate or severe pain following the surgical removal of impacted third molars. Estimates of the relative potency of proquazone to aspirin ranged from 4.9 to 6.2 for total analgesic effect and from 7.7 to 8.4 for peak analgesic effect. Each dosage level of proquazone and aspirin provided significant analgesia compared to placebo and was well tolerated. Adverse effects were transitory and did not appear to be dose related for proquazone.
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J. A. Forbes, W. T. Beaver, E. H. White, R. W. White, G. B. Neilson, and R. W. Shackleford
Diflunisal: A New Oral Analgesic With an Unusually Long Duration of Action
JAMA, November 5, 1982; 248(17): 2139 - 2142.
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