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Ketazolam and diazepam in anxiety: a controlled study

K Rickels, I Csanalosi, P Greisman, MJ Mirman, RJ Morris, CC Weise, and G Weiss

Ketazolam (both in once-daily and three-times-daily dosing), diazepam, and placebo were compared for effectiveness in relieving anxious symptomatology in a clinical trial conducted with a total of 222 anxious, non-psychotic outpatients. Results indicated that improvement occurred early in treatment, that ketazolam was equally effective in both once-daily and three-times-daily dosing, and that ketazolam was similar in effect to diazepam. Ketazolam (both once-daily and three-times-daily) and diazepam were significantly (P < 0.05) better than placebo in alleviating symptoms of anxiety, as measured by the Hamilton Anxiety Scale, the Covi Anxiety Scale, and a physician-rated measure of global improvement.
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P Gill, A C Dowell, R D Neal, N Smith, P Heywood, and A E Wilson
Evidence based general practice: a retrospective study of interventions in one training practice
BMJ, March 30, 1996; 312(7034): 819 - 821.
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