J Clin Pharmacol
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Plasma protein binding of d-propoxyphene in normal subjects and anephric patients

KM Giacomini, TP Gibson, and G Levy

The free fraction of d-propoxyphene in the plasma of normal subjects is 0.24 +/- 0.02 (mean +/- S.D.) and is not concentration dependent in the usual therapeutic and toxic conentration range. Renal failure and relatively high concentrations of d-norpropoxyphene, the major metabolite of d-propoxyphene, have no significant effect on the plasma protein binding of d-propoxyphene.
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This article has been cited by other articles:


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 Hum Exp ToxicolHome page
R.M. Pearson
Pharmacokinetics of Propoxyphene
Human and Experimental Toxicology, January 1, 1984; 3(1_suppl): 37s - 40S.
[PDF]

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 ANN INTERN MEDHome page
W. M. BENNETT, R. S. MUTHER, R. A. PARKER, P. FEIG, G. MORRISON, T. A. GOLPER, and I. SINGER
Drug Therapy in Renal Failure: Dosing Guidelines for Adults: Part I: Antimicrobial Agents, Analgesics
Ann Intern Med, July 1, 1980; 93(1_Part_1): 62 - 89.
[Abstract] [PDF]


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