J Clin Pharmacol
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Journal of Clinical Pharmacology, 1976; 16:367-370
© 1976 the American College of Clinical Pharmacology

Articles

Oral terbutaline sulfate--amelioration of exercise-induced bronchospasm

J Allegra, J Field, J Trautlein, M Gillin, and R Zelis

Bronchospasm can be induced in asthmatics when exercised according to a multistage branching treadmill protocol that allows them to achieve 80 per cent of their age-predicted maximal heart rate. This present study was undertaken to investigate the effect of oral terbutaline sulfate in ameliorating exercise-induced bronchospasm. Ten asthmatics were exercised, and FEV1.0 and MMEFR were assessed while standing, using a Jones Pulmonar II waterless spirometer at 5, 15, and 30 minutes after exercise. Three hours before exercise, the subjects received no medication, oral placebo, or 5 mg terbutaline sulfate orally. At all time intervals after exercise, the pulmonary function of the group pretreated with oral terbutaline was superior when compared to the no-medication group (P less than 0.01) and to the placebo-treated group (P less than 0.05). Oral terbutaline appeared to normalize the exercise tolerance of the asthmatics and restore physiologic pulmonary airway conductance by the parameters of FEV1.0 and MMEFR.
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R. M. Sly
Correspondence: Aerosolized Terbutaline in Exercise-Induced Bronchospasm
J. Clin. Pharmacol., April 1, 1977; 17(4): 266 - 267.
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Copyright © 1976 by the American College of Clinical Pharmacology