Pharmacokinetics of Fluorocarbon 11 and 12 in Dogs and Humans

¹ Departments of Pharmacy and Pharmacology-Toxicology, School of Pharmacy, University of Maryland, the Departments of Pharmacology and Obstetrics and Gynecology, School of Medicine, The Johns Hopkins University; Department of Anesthesiology, School of Medicine, University of Maryland, Baltimore, Maryland.

Blood levels and exhalation bag contents of FC-11 and FC-12 from dogs and humans were used to elucidate the pharmacokinetic model describing the time course of these agents. The derived pharmacokinetic parameters were in good agreement with the physicochemical properties of these substances. The model was used to estimate the percentage of dose absorbed, which averaged 77 per cent for FC-11 and 55 per cent for FC-12, and to predict the level of FC-11 and FC-12 under a variety of conditions simulating both short- and long-term exposure to the maximum allowable concentrations of these agents. With similar doses, an 8-hour continuous exposure was estimated to produce levels of FC-11 and FC-12 that are much lower than the corresponding levels reported to induce cardiac sensitization in dogs.

Note:

This study was supported by a contract from the Cosmetic, Toiletry, and Fragrance Association, Inc., and a grant from the Computer Center of the University of Maryland at College Park. The expert assistance of Mr. Gordon Jarman in the computer analysis of the data is gratefully acknowledged. The authors thank Mr. Milo Gibaldi, Professor and Chairman of the Department of Pharmaceutics, State University of New York at Buffalo, for his valuable suggestions in the preparation of this manuscript.

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