J Clin Pharmacol
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The Journal of Clinical Pharmacology, 1975; 15:752-759
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Lorazepam Compared with Pentobarbital for Nighttime Sedation

P. J. Brown M.A.C.D.1, W. H. Forrest Jr. M.D.1, and C. R. Brown F.F.A.R.A.C.S.1

1 Departments of Anesthesia, Stanford University School of Medicine and Veterans Administration Hospital, Palo Alto, California.

Lorazepam (0.5, 1, 2, and 4 mg) was compared with pentobarbital (60 and 180 mg) for its effects on sleep in "hospital insomniacs" Subjective-response data were collected by research nurses. Lorazepam was found to be a potent nighttime sedative: 1 to 1.25 mg of lorazepam is equivalent to 100 mg sodium pentobarbital for measures of sleep quality and duration. At this dose level it is less effective than 100 mg of pentobarbital as a sleep inducer. Studies at higher doses (up to 4 mg) indicate that lorazepam has a wide therapeutic index.

Note:

This work was done within the framework of the Veterans Administration Cooperative Analgesic Study in which the principal investigators at the time of the study were Drs. Grete Teutsch, Donald L. Mahler, William H. Forrest, Jr., Colin R. Brown, H. Earl Gordon, and Martin Gold.

We wish to acknowledge the assistance of Carol Canup, R.N., Chief nurse-observer.


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Copyright © 1975 by the American College of Clinical Pharmacology