Plasma Concentrations and Bioavailability of Clofibrate After Administration to Human Subjects

¹ Department of Metabolism and Pharmacokinetics, Huntingdon Research Centre, Huntingdon PE18 6ES, U.K.

After an oral dose of clofibrate (Atromid-S, I.C.I.; or Liprinal, Bristol-Myers) in capsule form (2X500 Gm), peak plasma concentrations of the bioactive metabolite, p-chlorophenoxyisobutyric acid, were reached 2 to 8 hours after administration and ranged between 43 and 79 µg/ml. Mean peak concentrations were almost identical (55 µg/ml) and were reached 6 hours after administration of either formulation. During the first 12 hours after administration, the bioavailability of p-chlorophenoxyisobutyric acid from Liprinal relative to Atromid-S was 98 per cent, and statistical analysis indicated that there was no significant difference between the rate and extent of absorption of drug from either formulation.

Note:

The authors are grateful to Dr. P. Gooding of the Bristol-Myers Company International, New York, for his help and interest and the opportunity to do these studies.

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