Diazepam and Meperidine on Arterial Blood Gases in Healthy Volunteers

¹ Department of Anesthesiology, University of Michigan Medical Center, Ann Arbor, Michigan 48104.

Arterial blood gases were not significantly altered by 0.15 mg/kg I.V. dose of diazepam in healthy volunteers. The PaO₂ was significantly reduced and the PaCO₂ increased following the administration of meperidine 1.5 mg/kg intravenously and the combination of meperidine 1.5 mg/kg with diazepam 0.15 mg/kg. Diazepam did not significantly increase the respiratory depression induced by meperidine. Values for arterial pH were not significantly affected in any of the groups.

Note:

We are grateful to Hoffmann-La Roche Inc. for their generous support of our in vestigations and for the statistical analysis of the data.

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