Psychomotor Test Performance with a Fenfluramine-Amphetamine Combination

¹ Baltimore, Md.

Twenty-four normal, non-obese subjects were administered a battery of ten psychomotor tests on five consecutive days. They performed before drug administration and at 45, 90, 150, and 210 minutes after ingestion. Four treatments were used: 10 mg dextroamphetamine, 30 mg fenfluramine, a combination of the two doses, and a placebo. The study was double blind and all orders of administration were used. Findings reveal significance on six out of the ten tests, usually between dextroamphetamine and placebo. Fenfluramine alone did not significantly differ from placebo on any test. The combination of drugs produced performances similar to that of dextroamphetamine alone. Further study is suggested.

Note:

Thanks are due Dr. Althea Wagman for her invaluable advice in statistical analysis.

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