J Clin Pharmacol
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The Journal of Clinical Pharmacology, 1974; 14:345-353
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DMSO: A New Respiratory Stimulant?

J. C. de la Torre S.M., Sc.D.,1 and D. W. Rowed M.D.1

1 Chicago, III.

Dimethyl sulfoxide (DMSO) was shown to markedly protect rats from hypoxic death after rats were exposed to a pure nitrogen gas atmosphere in a closed chamber. The effects of DMSO were evaluated in relation to two known respiratory stimulants, doxapram and ethamivan, and to phenobarbital. Doxapram but not ethamivan, phenobarbital, or saline significantly protected rats from the hypoxic stress.

In further evaluating doxapram and DMSO, the latter was found to be more protective of hypoxic death when the nitrogen exposure to rats was increased. Determination of respiratory minute volumes (RMV) and respiratory rate (RR) in rhesus monkeys indicates that the DMSO effect on RMV and RR is stronger and of longer duration than that of doxapram or ethamivan. Urea and various volumes of saline were without effect in these animals.

The results of these findings are discussed in relation to the possible respiratory stimulant activity of DMSO.


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