J Clin Pharmacol
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Sign In to gain access to subscriptions and/or personal tools.
The Journal of Clinical Pharmacology, 1974; 14:271-279
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brunk, S. F.
Right arrow Articles by Wilson, W. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brunk, S. F.
Right arrow Articles by Wilson, W. R.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Effects of Hypothyroidism and Hyperthyroidism on Dipyrone Metabolism in Man

S. Fred Brunk M.D.1, Steven P. Combs M.D.1, John D. Miller M.D.1, Margrieta Delle M.S.1, and William R. Wilson M.D.1

1 Department of Internal Medicine (Division of Clinical Pharmacology) and the Department of Pharmacology, University of Iowa College of Medicine, Iowa City, Iowa 52242.

The effect of hypothyroidism on dipyrone metabolism was studied in six patients, and the effect of hyperthyroidism in two patients. These patients were studied both before and after appropriate treatment.

In the hypothyroid subjects, plasma dipyrone levels were elevated and urinary excretion of 4-aminoantipyrine was decreased; treatment with liothyronine partially corrected this. In the hyperthyroid subjects, plasma dipyrone levels were normal and the urinary excretion of 4-aminoantipyrine was decreased; treatment increased the excretion of 4-aminoantipyrine toward normal.

These findings suggest that in man an absence of thyroid hormone decreases the N-demethylation of dipyrone and that excessive endogenous thyroid hormone may have a similar effect.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1974 by the American College of Clinical Pharmacology