J Clin Pharmacol
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The Journal of Clinical Pharmacology, 1974; 14:264-270
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Bioavailability Studies of Acetaminophen and Nitrofurantoin

K. S. Albert Ph.D.1, A. J. Sedman 1, P. Wilkinson 1, R. G. Stoll Ph.D.2, W. J. Murray M.D., Ph.D.3, and J. G. Wagner Ph.D.1

1 College of Pharmacy and Upjohn Center for Clinical Pharmacology, University of Michigan, Ann Arbor, Mich.
2 Clinical Bioavailability Unit, The Upjohn Company, Kalamazoo, Mich.
3 Department of Anesthesiology, Duke University Medical center, Durham, N. C.

In two test panels of ten subjects each, plasma levels and urinary excretion of two drugs, acetaminophen and nitrofurantoin, were measured in order to compare bioavailabilities when the drugs were formulated as commercial tablets and as specially formulated gelatin capsules. No significant differences in relative efficiency of absorption were obtained between tablets and capsules with either drug. However, when comparing rates of absorption, the soft gelatin capsule appeared slightly superior to the tablet in the nitrofurantoin study, whereas it appeared slightly inferior to the tablet in the acetaminophen study. The differences were not striking with either drug.


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