J Clin Pharmacol
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The Journal of Clinical Pharmacology, 1974; 14:215-218
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Antipyresis with Fenoprofen

Charles M. Gruber JR. M.D., D.Sc.(Med.)1

1 Lilly Laboratory for Clinical Research, Marion County General Hospital; Indiana University School of Medicine, Indianapolis, Indiana 46202.

Eight doses of fenoprofen calcium, 400 mg, acid equivalents, were administered every six hours to patients with chronic disease and associated fever. In comparison with placebo treatment before and after, fenoprofen significantly suppressed the febrile state of each individual. Subnormal temperatures occurred commonly during the treatment period. Subnormal temperatures were not observed when single oral doses of 600 mg were given to normal subjects.

Note:

We wish to thank each of the subjects who participated in this study. Also, recognition must be given to the many ancillary medical personnel who contributed through care of these subjects and compliance with the requirements of the protocol. Special consideration is reserved for Mr. Thomas L. Collins and Mr. Jewell M. Vidito, who made the thermocouple method possible, and Drs. Alfons Landwehr, Morgan Greene, and Richard W. Dyke, whose patients cooperated in this investigation.


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Copyright © 1974 by the American College of Clinical Pharmacology