J Clin Pharmacol
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The Journal of Clinical Pharmacology, 1974; 14:163-165
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Adsorption of Bile by Aluminum Hydroxide

Julius Wenger M.D.1 and Steven Heymsfield M.D.1

1 Department of Medicine, Emory University School of Medicine and Veterans Administration Hospital (Atlanta), Decatur, Ga. 30033.

When diluted antacid suspensions containing aluminum hydroxide (Amphogel and Wingel) were incubated with bilestained gastric contents or human "Ttube" bile, bile salts and bilirubin were removed from the supernatant fluid. The maximum efficiency of this process in vitro is between pH 4 and 6.5.

On the basis of animal studies, a rise in intragastric pH and reduction in bile salt concentration should reduce injury to the gastric mucosa.

To evaluate the treatment of "bile reflux gastritis" in patients, clinical studies should include these mixtures containing aluminum hydroxide.

Note:

Technical assistance by Miss Marian Sundy is acknowledged.


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 Arch SurgHome page
G. D. Cousar and T. R. Gadacz
Comparison of Antacids on the Binding of Bile Salts
Arch Surg, September 1, 1984; 119(9): 1018 - 1020.
[Abstract] [PDF]


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