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The Journal of Clinical Pharmacology and New Drugs, 1973; 13:44-47
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A Comparison of Fluspirilene and Trifluoperazine in the Treatment of Acute Schizophrenic Psychosis

Robert G. Bankier M.B., Ch.B., M.Sc., M.R.C.Psych., F.R.C.P.(C)1

1 University of Manitoba; Hospital for Mental Diseases, Selkirk, Manitoba, Canada.

A group of ten acutely disturbed schizophrenic patients was treated over a period of 16 weeks with I.M. fluspirilene once weekly and compared with a group of 12 patients treated with oral trifluoperazine in twice daily doses. No significant differences were found in the therapeutic efficacy of the two drugs, but extrapyramidal toxic reactions were much more common in the trifluoperazine group. Both drugs were found to be highly effective in controlling the symptoms of psychosis.

Note:

The author is grateful to Dr. M. C. Kovacs, medical superintendent, Selkirk Mental Hospital, for permission to study these patients, and to Mr. D. E. Pettit, director of clinical psychology, for assistance with the statistical analysis of data. Thanks are also due to the medical staff and nursing staff for their cooperation and to Miss Doreen Massey and Miss Darlene Thordarson for stenographic assistance. The study was given financial support by McNeil Laboratories (Canada) Ltd., who also supplied all medications.


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