J Clin Pharmacol
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The Journal of Clinical Pharmacology and New Drugs, 1973; 13:36-40
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Cephradine Absorption and Excretion in Fasting and Nonfasting Volunteers

C. Harvengt M.D.1, P. de Schepper M.D.1, F. Lamy M.D.1, and J. Hansen B.Sc.1

1 Laboratory of Pharmacotherapy and Pharmacology, University of Louvain, Belgium; Clinical Research Department, R.I.T., Genval, Belgium.

Serum concentrations and urinary excretion of cephradine and cephalexin, administered in a cross over fashion, are compared in 12 healthy volunteers, six fasting and six nonfasting. Each antibiotic was administered in a single oral dose of 500 mg.

Microbiological assays showed that absorption of either cephradine or cephalexin is rapid and virtually complete. High serum levels and urinary concentrations are reached both in fasting and nonfasting volunteers with both antibiotics. Absorption and excretion are, however, some what more rapid in fasting than in non fasting volunteers.

More than 85 per cent of the administered dose is already recovered in the urine in the first 6 hours following ingestion of both drugs. The excreted product is microbiologically active.

Note:

We would like to acknowledge the help of Dr. B. Boon, Microbiological Research, R.I.T., Genval, Belgium, for the microbiological assays performed for this study.


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Copyright © 1973 by the American College of Clinical Pharmacology