J Clin Pharmacol
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The Journal of Clinical Pharmacology and New Drugs, 1973; 13:28-35
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The Respiratory Effects of Pentobarbital and Secobarbital in Clinical Doses

Colin R. Brown M.B., B.S., F.F.A.R.A.C.S.1, William H. Forrest JR. M.D.1, and Johan Hayden R.N.1

1 Departments of Anesthesia, Stanford University School of Medicine, Stanford, California; Veterans Administration Hospital, Palo Alto, California.

The respiratory depressant effects of pentobarbital and secobarbital were compared in a randomized double-blind cross-over study in human volunteers. Using a rebreathing technique, carbon dioxide response curves were plotted automatically with a special-purpose analog computer. The respiratory depressant relative potency of pentobarbital to secobarbital was found to be 1.38, with lower and upper 95 per cent confidence limits of 0.66 and 6.03. Our best estimate, based on the displacement of the respiratory response curve, is that 70 mg of secobarbital is approximately equivalent to 100 mg of pentobarbital in our population of volunteers.

Note:

We are grateful to our staff of nurse observers, programmers, technical assistants, and secretaries, and in particular to Ken James, Ph.D., Anna Marie Demeter, and John Haxo.


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