Sodium Cellulose Phosphate: Mechanism of Action and Effect on Mineral Metabolism

¹ Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Tex. 75235.

Oral sodium cellulose phosphate inhibited intestinal absorption of calcium probably by "binding" dietary and secreted pools of calcium and restricting the amount of calcium available for absorption. An impairment of calcium absorption led to a decrease in the ultrafiltrable serum calcium and the renal filtered load of calcium, and hence to a reduction in the renal excretion of calcium. The urinary state of saturation with respect to brushite (probable nidus of calcium stones) decreased during treatment, probably as the result of a fall in urinary calcium. Urinary phosphorus increased slightly; this probably reflected largely the absorption of phosphorus released from cellulose phosphate by hydrolysis in the gastrointestinal tract. Cellulose phosphate did not turn more negative the state of calcium balance. Further, it did not affect significantly the metabolism of copper, zinc, sodium, and potassium, or the endogenous creatinine clearance.

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