J Clin Pharmacol
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Sign In to gain access to subscriptions and/or personal tools.
The Journal of Clinical Pharmacology and New Drugs, 1972; 12:89-94
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zsotér, T. T.
Right arrow Articles by Gospodarowicz, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zsotér, T. T.
Right arrow Articles by Gospodarowicz, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

The Effect of Diazepam and Pentazocine on the Venomotor Reflexes in Man

Thomas T. Zsotér M.D., F.R.C.P.(C), F.A.C.P.1 and Maria Gospodarowicz M.D.1

1 Division of Clinical Pharmacology, Toronto Western Hospital, University of Toronto, Toronto, Canada.

The effect of diazepam and pentazocine on venomotor reflexes was studied. Diazepam 10 or 6 mg intravenously in 15 volunteers decreased blood flow and venous tone in the forearm. Venoconstriction caused by Valsalva maneuver was markedly diminished after the drug. Venomotor reflexes activated by deep inspiration or hyperventilation were also depressed, but less consistently. Pentazocine 0.75 mg/kg intravenously in 15 other volunteers had no significant effect on forearm venous tone. Venoconstriction induced by Valsalva maneuver became less pronounced after the drug was given, but changes in heart rate were not altered. Results indicate that venomotor reflexes may be affected by drugs that have no effect on the peripheral autonomic nervous system but that act on the central nervous system.

Note:

The skillful technical assistance of Mrs. Sheila Clayton and Mrs. Anna Blascovich is gratefully acknowledged.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1972 by the American College of Clinical Pharmacology