Cephapirin: Pharmacology in Normal Human Volunteers

¹ Division of Infectious Diseases, Department of Medicine, The Mount Sinai School of Medicine of the City University of New York, 100th Street and Fifth Avenue, New York, N.Y. 10029.

One gram of cephapirin, a new semisynthetic cephalosporin derivative, was injected either intravenously or intramuscularly into healthy volunteers. Serum levels were measured at timed intervals for 6 hours after administration of the drug. A peak serum level of 72.6 µg/ml was observed hour after the intravenous dose followed by a rapid decline, and a peak level of 24.2 µg/ml was obtained hour after the intramuscular dose. During the first 6 hours following injection, 72% and 53% of the 1-Gm intravenous and intramuscular doses of cephapirin, respectively, were excreted in the urine.

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