Effect of Beta-Blocking Drug Propranolol on ¹³¹I Utilization in Euthyroid Patients

¹ Departments of Oncology and Applied Pharmacology, Hadassah University Hospital and Hebrew University—Hadassah Medical School, Jerusalem, Israel.

The effect of the beta-blocking drug propranolol on the radioutilization of the thyroid gland in 20 euthyroid patients was studied. The ¹³¹I uptake was normal in all patients before treatment and remained unaltered by the daily administration of 40 mg propranolol for 30 to 45 days. In eight patients, the dose was raised to 80 mg/day and repeat ¹³¹I uptake was performed 30 to 45 days later; this examination, too, was not significantly different from the previous ones. These results demonstrate that propranolol in the above doses does not affect iodine uptake of the thyroid gland.

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