J Clin Pharmacol
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The Journal of Clinical Pharmacology and New Drugs, 1971; 11:456-460
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Comparison of Chlordiazepoxide-Amitriptyline Combination with Amitriptyline Alone in Anxiety-Depressive States

Henry P. Hare JR. M.D.1

1 San Antonio, Texas

The efficacy of Limbitrol (chlordiazepoxide-amitriptyline) was compared with that of amitriptyline alone in two double blind studies comprised of 20 patients each with psychoneurotic depressive and mixed anxiety-depressive reactions treated for five to six weeks. The results of the study, which were statistically significant, substantiated previous observations by others that many neurotic depressed patients benefit most from combined antidepressant-antianxiety therapy. Side effects were those seen usually with the individual components of the combination and consisted most often of transient drowsiness and dryness of mouth.


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Copyright © 1971 by the American College of Clinical Pharmacology