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The Journal of Clinical Pharmacology and New Drugs, 1971; 11:332-348
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Clinical Pharmacologic Studies with Minocycline

Betty Bernard M.D.1, Elaine Jong Yin B.A.1, and Harold J. Simon M.D., Ph.D.1

1 Department of Community Medicine, School of Medicine, University of California, San Diego, La Jolla, Calif. 92037.

Clinical pharmacologic studies with MINO were carried out on normal subjects and on patients with hepatic or renal dysfunction. Serum half-life of 13.7 hours in normal ambulatory controls given MINO in the daytime was one of the longest reported for tetracycline homologues, and was independent of administered dose, time of administration, and hepatic dysfunction. Serum half-life was significantly prolonged by renal dysfunction.

Bed rest and fasting significantly elevated peak serum concentrations, fractional urinary excretions, and urinary concentrations of MINO in normal individuals, but not in hospitalized patients with renal or hepatic dysfunction.

Circadian influences did not demonstrably affect the clinical pharmacology of MINO.

Note:

The technical assistance of Elizabeth B. Howell is gratefully acknowledged. The authors also wish to express their appreciation to members of the UCSD School of Medicine Charter Class and their wives (Bruce Adornato, J. Woodruff and Mary Emlen, William and Brenda Jessee, Gregory and Ikonija Joy, William and Karen Piggott, Richard Rosenblatt, and David and Jean Smith) for their cooperation and attention to experimental details as participants in this study. The cooperation of the personnel at the University Hospital of San Diego County Clinical Laboratories (Naomi Williams, Elizabeth Renteria, Janice Shapcott, and Phillip Payne) is greatly appreciated and acknowledged.


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