J Clin Pharmacol
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The Journal of Clinical Pharmacology and New Drugs, 1970; 10:203-206
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The Behavioral Pharmacology of Oxypertine

James Claghorn M.D.1 and Joseph C. Schoolar Ph.D., M.D.1

1 Texas Research Institute of Mental Sciences, Baylor University College of Medicine, and The University of Texas Graduate School of Biomedical Sciences, Houston, Tex.

Oxypertine is an indole-based compound with antipsychotic properties which other studies have indicated might be especially useful in aiding the psychotherapeutic treatment of withdrawn schizophrenics. This study compared the effects of oxypertine and chlorpromazine in 40 schizophrenic males using clinical evaluation, NOSIE, and BPRS scales. Effective dosage for oxypertine was established at approximately 300 mg daily and there were fewer side effects reported for the oxypertine group than for the chlorpromazine group. Chlorpromazine was effective in more BPRS items than oxypertine and is a more sedative drug.

Note:

I wish to express my appreciation to Mrs. Joyce McReynolds and Mrs. Gerri Blauser for their assistance in this study.


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