Treatment of Acute Intermittent Porphyria With Adenosine-5-Monophosphate: A Long-Term Double-Blind Study

¹ Psychiatric Research Centre, University of Uppsala, Sweden.

Adenosine-5-monophosphate has been used as treatment of acute intermittent porphyria, although its therapeutic value has not been proved. In this study a double-blind investigation of six months' duration is reported. Thirty-two patients with acute intermittent porphyria received for one month at a time the drug adenosine-5-monophosphate sublingually in a dose of 225 mg daily or matching placebo, alternating every month and starting in randomized order. There were 96 patient months on active drug and 96 months on placebo. A comparison of the overall state of health and the urinary excretion of -aminolaevulinic acid and porphobilinogen was made at the end of each month. It was not possible to show any difference in the overall state of health or the biochemical tests between the periods the patients were on active drug and the periods they received placebo.

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