J Clin Pharmacol
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The Journal of Clinical Pharmacology and New Drugs, 1970; 10:165-170
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Methodological Considerations in the Histamine Skin Test

L. Joubert M.D., M.Sc.1 and G. B. Thomas B.S.2

1 Department of Clinical Pharmacology, Hoffmann-La Roche, Nutley, N.J.
2 Hoffmann-La Roche, Nutley, N.J.

Data are presented showing that despite high reproducibility, the histamine skin test is highly variable. The wheal and flare responses are independent variables. Methodological considerations are suggested for the design of a comparative antihistamine trial when using the wheal response as a bioassay test.

Note:

The authors wish to express their gratitude to Dr. Walter Herzog and Mr. Robert O. Guillaume of Cintest, Inc., Miamiville, Ohio, for their help in the conduct of the experiment, and to Dr. W. B. Abrams and Mr. T. Lewinson for valuable discussion during the preparation of this manuscript.


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