J Clin Pharmacol
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The Journal of Clinical Pharmacology and New Drugs, 1970; 10:161-164
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Effect of Anticholinergic Agents on Ciliary Muscle of the Eye

Yoshiharu Sakamoto M.D., Ph.D.1, Yukitsura Tanabe M.D.1, and Masahiro Imaizumi M.D.1

1 Department of Ophthalmology, Osaka City University Medical School, Oska, Japan.

A new synthetic anticholinergic drug, prifinium bromide (PFB), was compared with hyoscine butylbromide (HBB) and benactyzine methylbromide (BMB) with regard to its action on the ciliary muscle (near-point accommodation), pupillary diameter, and heart rate.

All three drugs reduced near-point accommodation. The inhibiting action of PFB tended to increase with dosage and that of HBB was particularly manifest.

In the doses used none of the three drugs had any influence upon pupillary diameter.

All three drugs increased and had a longer lasting effect on the heart rate with increase in dosage. BMB was the most potent in this regard.

There was no correlation between effectiveness of the three drugs on accommodation and heart rate. All three drugs had a slower onset of action on nearpoint accommodation than on the heart rate, a phenomenon which the authors consider to be common to all types of anticholinergic drugs.


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