J Clin Pharmacol
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The Journal of Clinical Pharmacology and New Drugs, 1970; 10:145-152
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Comparison of a Partially Synthetic Glycoside Strophanthidin-Arabinoside with Ouabain and Digitalis in Patients with Auricular Fibrillation

Harry Gold M.D.1, Theodore Greiner M.D.1, William Zahm M.D.1, and K. K. Chen M.D.1

1 Cornell University Medical College, Hospital for Joint Diseases and Medical Center, and Cardiovascular Research Unit of the Beth Israel Medical Center, New York, N.Y.; Indiana University Medical Center, Indianapolis, Ind.

The semisynthetic glycoside, strophanthidin-arabinoside, was studied in eight patients with auricular fibrillation and moderate congestive failure. By intravenous injection this drug exerts the typical digitalis-like action in slowing the ventricular rate. Its potency and curve of action are similar to ouabain. The effect appears almost immediately after injection and develops fully in about an hour or less. The action persists for about ten hours and disappears in 24 hours or somewhat sooner. Absorption after oral administration is negligible. The curve of action is practically identical with that of ouabain. The results indicate that strophanthidin-arabinoside can serve as a substitute for ouabain for rapid digitalization by the intravenous route.


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